Clinical Profile of Patients with Cirrhosis of Liver having Refractory Ascites, in a Tertiary Care Centre of Western India

Background and Aim: Ascites occurs at the rate of 7-10% annually in cirrhotic patients. Within 10 years diagnosis cirrhosis, 70% patients will develop ascites. First-line therapy for with ascites is sodium restriction diuretics. Eventually, up to 11.4% refractory (RA), defined as that cannot be mobilized or early recurrence which (i.e., after paracentesis) satisfactorily. prevented by diuretic therapy. This a cross-sectional observational. study, aims observe cirrhosis liver, presenting developing refractory. ascites, their ongoing medications, complications course disease. Methods: A data 169 consecutive admitted Bombay Hospital Medical Research Centre, ranging age from 18 85 years, collected over time period 01.10.2019 30.09.2021. All were meticulously monitored, systematic record clinical parameters, investigations, medications maintained later analyzed. Results: Of 50 (29.58%) had Alcohol related seen 21 (42%) patients, was most common cause cirrhosis. The mean spot urinary Na+/K+ ratio these 1.92±0.51, found significantly lower when compared sensitive cirrhotics. MELD-Na CTP score among 26.74 10.48/C respectively. Forty (80%) died, 14(28%) are on regular follow 3(6%) have undergone. successful liver transplant during study period, suggesting higher mortality Conclusion: Refractory relatively uncommon challenging complication high morbidity mortality. Currently, salt restricted diet, diuretics, repeated large volume paracentesis albumin infusion, TIPS ultimately only approved treatment management Further studies required better